Wednesday, August 15, 2018

Session III: Old and New Therapeutic Approaches in Metabolic Disease and Cancer

Session Chair: Roger Newton, PhD

7:30 AM Breakfast Buffet (Grand Ballroom Foyer)

8:30 AM  Franz Simon Poster Award/Introduction – Recipients To be Announced - Moshe Levi, MD, President, Kern Lipid Conference/Georgetown University

8:45 AM  “Liver-specific Inhibition of ATP-Citrate Lyase by Bempedoic Acid Decreases LDL Cholesterol and Atherosclerosis” - Stephen L Pinkosky PhD, Esperion Therapeutics

9:20 AM “The ATP-Citrate Lyase Inhibitor, Bempedoic Acid, Lowers LDL-Cholesterol and Attenuates Atherosclerosis in LDL Receptor Deficient Yucatan Miniature Pigs" - Murray Huff, PhD, Murray Huff, PhD, Medicine, Robarts Research Institute, University of Western Ontario”

9:55 AM Break

10:20 AM Joint Presentation: “The discovery and development of ACC inhibitors for NASH: A tag team between industry and academia” - Rosana Kapeller, MD, PhD, Former CSO of Nimbus Therapeutics and Bryan Fuchs, PhD, Harvard Medical School

11:20 AM “Metabolic Sensing by AMPK and its Potential as a Therapeutic Target for Treating Metabolic Disease and Cancer” - Gregory Steinberg, PhD, McMaster University, Ontario

12:00 PM Lunch (Mountain View Patio)

1:20 PM Introduction by Co-Chair Sam Klein, MD,Washington University School of Medicine

1:25 PM “Acetyl-CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation” - Jay D. Horton, MD, University of Texas-Southwestern

1:55 PM “Isotope Tracing Untargeted Metabolomics Reveals Novel Roles for Ketone Metabolism in Nonalcoholic Fatty Liver Disease” - Peter Crawford, MD, PhD, University of Minnesota

2:30 PM Young Investigator Abstract Presentation: “Scaffolding protein IQGAP1 as a key regulator of long-term ketosis” - Hanna Erickson, MD/PhD Student, University of Illinois at Urbana-Champaign

2:45 PM Young Investigator Abstract Presentation: “Mitochondrial DNA Repair on Protection Against Obesity & Metabolic Syndrome” - Sai Santosh Babu Komakula, PhD Student, Rutgers University

3:00 PM Break

3:15 PM “Identification and Validation of New Targets Using Precision Phenotyping and Panomics” - Szilard Voros MD, Global Genomics Group

3:50 PM “Using Mendelian Randomization to Identify and Validate Novel Therapeutic Targets” - Brian A Ference, MD, MPhil, MSc, University of Cambridge

4:25 PM Young Investigator Abstract Presentation: “Loss of Whole Body Perilipin-2 Imparts Profound Susceptibility to Carbohydrate-Mediated Browning of White Adipose Tissue” - Andrew Libby, PhD, University of Colorado Anschutz Medical Campus

4:40 PM Young Investigator Abstract Presentation: “Exploring a Novel CD8 T cell that Modulates Cardiovascular Disease Progression” - Lindsey E. Padgett, PhD, La Jolla Institute for Allergy and Immunology

4:55 PM Adjourn

6:30 PM Dinner and Reception (Grand Ballroom)