Wednesday, August 15, 2018

Session III: Old and New Therapeutic Approaches in Metabolic Disease and Cancer

Session Chair: Roger Newton, PhD

7:30 AM Breakfast Buffet (Grand Ballroom Foyer)

8:30 AM  Franz Simon Poster Award/Introduction – Recipients To be Announced - Moshe Levi, MD, President, Kern Lipid Conference University of Colorado, Aurora, Colorado

9:00 AM  “Liver-specific Inhibition of ATP-Citrate Lyase by Bempedoic Acid Decreases LDL Cholesterol and Atherosclerosis” - Stephen L Pinkosky PhD, Esperion Therapeutics

9:35 AM “ATP-Citrate Lyase Inhibitor, Bempedoic Acid, Lowers LDL-Cholesterol and Attenuates Atherosclerosis in LDL Receptor Deficient (LDLR +/- and LDLR -/-) Yucatan Miniature Pigs" - Murray Huff, PhD, Medicine, University of Western Ontario”

10:10 AM Break

10:20 AM “Acetyl CoA Carboxylase in the Cross-Roads of Immune-Cancer-Metabolism Regulation, Impact on Non-Alcoholic Steatohepatitis (NASH) and Cancer” - Rosana Kapeller, MD, PhD, Nimbus Therapeutics

10:55 AM “Acetyl-CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation” - Jay D. Horton, MD, Center for Human Nutrition, Internal Medicine and Molecular Genetics, University of Texas-Southwestern

11:30 AM Early Career Investigator Presentation (2018 Abstract) - TBD

12:00 PM Lunch (Mountain View Patio)

1:20 PM “Metabolic Sensing by AMPK and its Potential as a Therapeutic Target for Treating Metabolic Disease and Cancer” - Gregory Steinberg PhD, Medicine, Endocrinology, McMaster University, Ontario

1:55 PM “Isotope tracing untargeted metabolomics reveals novel roles for ketone metabolism in nonalcoholic fatty liver disease” - Peter Crawford, MD, PhD, University of Minnesota

2:30 PM “Potentiating Anti-Tumor Response of CD8+ T Cells by Modulating Cholesterol Metabolism” - Chenqi Xu, PhD, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences”

3:00 PM Break

3:15 PM “Identification and Validation of New Targets Using Precision Phenotyping and Panomics” - Szilard Voros MD, Global Genomics Group

3:50 PM “In Silico Mendelian Genetics to Identify and Validate Novel Therapeutic Targets” - Brian Ference MD, Medicine, Cardiology, Wayne State University

4:25 PM Early Career Investigator Presentation (2018 Abstract) - TBD

5:15 PM Break

6:30 PM Dinner Reception (Grand Ballroom Salons F-J)

9:30 PM Adjourn